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Notch- and Transducin-like Enhancer of Split (TLE)-dependent Histone Deacetylation Explain Interleukin 12 (IL-12) p70 Inhibition by Zymosan

The fungal analog zymosan induces IL-23 and low amounts of IL-12 p70. This study addresses the molecular mechanisms underlying this cytokine pattern in human monocyte-derived dendritic cells. The transcriptional regulation of il23a, one of the chains of IL-23, depended on the activation of c-Rel and...

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Detalhes bibliográficos
Main Authors: Alvarez, Yolanda, Municio, Cristina, Hugo, Etzel, Zhu, Jimmy, Alonso, Sara, Hu, Xiaoyu, Fernández, Nieves, Crespo, Mariano Sánchez
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3089501/
https://ncbi.nlm.nih.gov/pubmed/21402701
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M111.222158
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