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Sirtuin 1 Is a Key Regulator of the Interleukin-12 p70/Interleukin-23 Balance in Human Dendritic Cells

Stimulation of human dendritic cells with the fungal surrogate zymosan produces IL-23 and a low amount of IL-12 p70. Trans-repression of il12a transcription, which encodes IL-12 p35 chain, by proteins of the Notch family and lysine deacetylation reactions have been reported as the underlying mechani...

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Detalhes bibliográficos
Main Authors: Alvarez, Yolanda, Rodríguez, Mario, Municio, Cristina, Hugo, Etzel, Alonso, Sara, Ibarrola, Nieves, Fernández, Nieves, Crespo, Mariano Sánchez
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471763/
https://ncbi.nlm.nih.gov/pubmed/22893703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.391839
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