Blocking TLR7- and TLR9-mediated IFN-α Production by Plasmacytoid Dendritic Cells Does Not Diminish Immune Activation in Early SIV Infection

Persistent production of type I interferon (IFN) by activated plasmacytoid dendritic cells (pDC) is a leading model to explain chronic immune activation in human immunodeficiency virus (HIV) infection but direct evidence for this is lacking. We used a dual antagonist of Toll-like receptor (TLR) 7 an...

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Detalhes bibliográficos
Main Authors: Kader, Muhamuda, Smith, Amanda P., Guiducci, Cristiana, Wonderlich, Elizabeth R., Normolle, Daniel, Watkins, Simon C., Barrat, Franck J., Barratt-Boyes, Simon M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2013
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723633/
https://ncbi.nlm.nih.gov/pubmed/23935491
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1003530
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