A Self-Assembling Short Oligonucleotide Duplex Suitable for Pretargeting

Monoclonal antibodies (mAbs) have naturally evolved as suitable, high affinity and specificity targeting molecules. However, the large size of full-length mAbs yields poor pharmacokinetic properties. A solution to this issue is the use of a multistep administration approach, in which the slower clea...

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Autori principali: Mallikaratchy, Prabodhika, Gardner, Jeffery, Nordstrøm, Lars Ulrik R., Veomett, Nicholas J., McDevitt, Michael R., Heaney, Mark L., Scheinberg, David A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Mary Ann Liebert, Inc. 2013
Soggetti:
Brief Report
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3723235/
https://ncbi.nlm.nih.gov/pubmed/23848521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/nat.2013.0425
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