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Synthesis of stable azide and alkyne functionalized phosphoramidite nucleosides
The use of CuAAC chemistry to crosslink and stabilize oligonucleotides has been limited by the incompatibility of azides with the phosphoramidites used in automated oligonucleotide synthesis. Herein we report optimized reaction conditions to synthesize azide derivatives of thymidine and cytidine pho...
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| Publicado no: | Tetrahedron Lett |
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| Main Authors: | , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6386463/ https://ncbi.nlm.nih.gov/pubmed/30804607 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2018.12.018 |
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