Synthesis of 8-(1,2,3-triazol-1-yl)-7-deazapurine nucleosides by azide-alkyne click reactions and direct C-H bond functionalization

Treatment of toyocamycin or sangivamycin with 1,3-dibromo-5,5-dimethylhydantoin in MeOH (r.t./30 min) gave 8-bromotoyocamycin and 8-bromosangivamycin in good yields. Nucleophilic aromatic substitution of 8-bromotoyocamycin with sodium azide provided novel 8-azidotoyocamycin. Strain promoted click re...

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Publicado no:Tetrahedron Lett
Main Authors: Kavoosi, Sam, Rayala, Ramanjaneyulu, Walsh, Brenna, Barrios, Maria, Gonzalez, Walter G., Miksovska, Jaroslava, Mathivathanan, Logesh, Raptis, Raphael G., Wnuk, Stanislaw F.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5322862/
https://ncbi.nlm.nih.gov/pubmed/28239199
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.tetlet.2016.08.053
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