HuR is required for IL-17-induced Act1-mediated CXCL1 and CXCL5 mRNA stabilization

IL-17, a major inflammatory cytokine plays a critical role in the pathogenesis of many autoimmune inflammatory diseases. In this study, we report a new function of RNA binding protein HuR in IL-17-induced Act1-mediated chemokine mRNA stabilization. HuR deficiency markedly reduced IL-17-induced chemo...

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Detalhes bibliográficos
Main Authors: Herjan, Tomasz, Yao, Peng, Qian, Wen, Li, Xiao, Liu, Caini, Bulek, Katarzyna, Sun, Dongxu, Yang, Wen-Pin, Zhu, Jun, He, Aiqing, Carman, Julie, Erzurum, Serpil, Lipshitz, Howard, Fox, Paul, Hamilton, Thomas, Li, Xiaoxia
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722902/
https://ncbi.nlm.nih.gov/pubmed/23772036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1203315
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