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Interleukin 17 treatment prolongs CXCL1 mRNA half-life via TRAF5 and the splicing regulatory factor SF2/ASF

Interleukin 17 (IL-17) promotes expression of chemokines and cytokines via induction of gene transcription and post-transcriptional stabilization of mRNA. We show that IL-17 enhanced the stability of CXCL1 and other mRNAs through a pathway that involves Act1, TRAF2 or TRAF5 and the splicing factor S...

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Main Authors: Sun, Dongxu, Novotny, Michael, Bulek, Katarzyna, Liu, Caini, Li, Xiaoxia, Hamilton, Thomas
Format: Artigo
Jezik:Inglês
Izdano: 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3597344/
https://ncbi.nlm.nih.gov/pubmed/21822258
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2081
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