Synergistic Combination Therapy with Nanoliposomal C6-Ceramide and Vinblastine is Associated with Autophagy Dysfunction in Hepatocarcinoma and Colorectal Cancer Models

Autophagy, a catabolic survival pathway, is gaining attention as a potential target in cancer. In human liver and colon cancer cells, treatment with an autophagy inducer, nanoliposomal C6-ceramide, in combination with the autophagy maturation inhibitor, vinblastine, synergistically enhanced apoptoti...

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Hauptverfasser: Adiseshaiah, Pavan P., Clogston, Jeffrey D., McLeland, Christopher B., Rodriguez, Jamie, Potter, Timothy M., Neun, Barry W., Skoczen, Sarah L., Shanmugavelandy, Sriram S., Kester, Mark, Stern, Stephan T., McNeil, Scott E.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2013
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3722309/
https://ncbi.nlm.nih.gov/pubmed/23664889
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.canlet.2013.04.034
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