CDK-mediated activation of the SCF(FBXO28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. SCF(FBXO28) activit...

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Bibliografische gegevens
Hoofdauteurs: Cepeda, Diana, Ng, Hwee-Fang, Sharifi, Hamid Reza, Mahmoudi, Salah, Cerrato, Vanessa Soto, Fredlund, Erik, Magnusson, Kristina, Nilsson, Helén, Malyukova, Alena, Rantala, Juha, Klevebring, Daniel, Viñals, Francesc, Bhaskaran, Nimesh, Zakaria, Siti Mariam, Rahmanto, Aldwin Suryo, Grotegut, Stefan, Nielsen, Michael Lund, Szigyarto, Cristina Al-Khalili, Sun, Dahui, Lerner, Mikael, Navani, Sanjay, Widschwendter, Martin, Uhlén, Mathias, Jirström, Karin, Pontén, Fredrik, Wohlschlegel, James, Grandér, Dan, Spruck, Charles, Larsson, Lars-Gunnar, Sangfelt, Olle
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: Blackwell Publishing Ltd 2013
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Research Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721474/
https://ncbi.nlm.nih.gov/pubmed/23776131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202341
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