CDK-mediated activation of the SCF(FBXO28) ubiquitin ligase promotes MYC-driven transcription and tumourigenesis and predicts poor survival in breast cancer

SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. SCF(FBXO28) activit...

Fuld beskrivelse

Na minha lista:
Bibliografiske detaljer
Main Authors: Cepeda, Diana, Ng, Hwee-Fang, Sharifi, Hamid Reza, Mahmoudi, Salah, Cerrato, Vanessa Soto, Fredlund, Erik, Magnusson, Kristina, Nilsson, Helén, Malyukova, Alena, Rantala, Juha, Klevebring, Daniel, Viñals, Francesc, Bhaskaran, Nimesh, Zakaria, Siti Mariam, Rahmanto, Aldwin Suryo, Grotegut, Stefan, Nielsen, Michael Lund, Szigyarto, Cristina Al-Khalili, Sun, Dahui, Lerner, Mikael, Navani, Sanjay, Widschwendter, Martin, Uhlén, Mathias, Jirström, Karin, Pontén, Fredrik, Wohlschlegel, James, Grandér, Dan, Spruck, Charles, Larsson, Lars-Gunnar, Sangfelt, Olle
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Publishing Ltd 2013
Fag:
Research Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721474/
https://ncbi.nlm.nih.gov/pubmed/23776131
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/emmm.201202341
Tags: Tilføj Tag
Ingen Tags, Vær først til at tagge denne postø!

Lignende værker