PTEN and DNA-PK determine sensitivity and recovery in response to WEE1 inhibition in human breast cancer

Inhibition of WEE1 kinase by AZD1775 has shown promising results in clinical cancer trials, but markers predicting AZD1775 response are lacking. Here we analysed AZD1775 response in a panel of human breast cancer (BC) cell lines by global proteome/transcriptome profiling and identified two groups of...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Brunner, Andrä, Suryo Rahmanto, Aldwin, Johansson, Henrik, Franco, Marcela, Viiliäinen, Johanna, Gazi, Mohiuddin, Frings, Oliver, Fredlund, Erik, Spruck, Charles, Lehtiö, Janne, Rantala, Juha K, Larsson, Lars-Gunnar, Sangfelt, Olle
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2020
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7338058/
https://ncbi.nlm.nih.gov/pubmed/32628111
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.57894
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