Nitric oxide controls tuberculosis immunopathology by inhibiting NLRP3 inflammasome-dependent IL-1β processing

Interleukin-1 (IL-1) is an important mediator of innate immunity, but can also promote inflammatory tissue damage. During chronic infections, such as tuberculosis, the beneficial antimicrobial role of IL-1 must be balanced with the need to prevent immunopathology. By exogenously controlling the repl...

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Bibliographische Detailangaben
Hauptverfasser: Mishra, Bibhuti B., Rathinam, Vijay A. K., Martens, Gregory W., Martinot, Amanda J., Kornfeld, Hardy, Fitzgerald, Katherine A., Sassetti, Christopher M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2012
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721324/
https://ncbi.nlm.nih.gov/pubmed/23160153
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ni.2474
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