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Sprouty genes regulate proliferation and survival of human embryonic stem cells

Sprouty (Spry) genes encode negative regulators of receptor tyrosine kinase (RTK) signaling, which plays important roles in human embryonic stem cells (hESCs). SPRY2 and SPRY4 are the two most highly expressed Sprouty family members in hESCs, suggesting that they may influence self-renewal. To test...

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Bibliographic Details
Main Authors: Felfly, Hady, Klein, Ophir D.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2013
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721083/
https://ncbi.nlm.nih.gov/pubmed/23880645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep02277
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