SIRT4 coordinates the balance between lipid synthesis and catabolism by repressing malonyl CoA decarboxylase

Lipid metabolism is tightly controlled by the nutritional state of the organism. Nutrient-rich conditions increase lipogenesis whereas nutrient deprivation promotes fat oxidation. In this study, we identify the mitochondrial sirtuin, SIRT4, as a novel regulator of lipid homeostasis. SIRT4 is active...

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Detalhes bibliográficos
Main Authors: Laurent, Gaëlle, German, Natalie J., Saha, Asish K., de Boer, Vincent C. J., Davies, Michael, Koves, Timothy R., Dephoure, Noah, Fischer, Frank, Boanca, Gina, Vaitheesvaran, Bhavapriya, Lovitch, Scott B., Sharpe, Arlene H., Kurland, Irwin J., Steegborn, Clemens, Gygi, Steven P., Muoio, Deborah M., Ruderman, Neil B., Haigis, Marcia C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3721068/
https://ncbi.nlm.nih.gov/pubmed/23746352
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2013.05.012
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