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Post-PKS Tailoring Steps of the Spiramycin Macrolactone Ring in Streptomyces ambofaciens

Spiramycins are clinically important 16-member macrolide antibiotics produced by Streptomyces ambofaciens. Biosynthetic studies have established that the earliest lactonic intermediate in spiramycin biosynthesis, the macrolactone platenolide I, is synthesized by a type I modular polyketide synthase...

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Autors principals: Nguyen, Hoang-Chuong, Darbon, Emmanuelle, Thai, Robert, Pernodet, Jean-Luc, Lautru, Sylvie
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3719765/
https://ncbi.nlm.nih.gov/pubmed/23716060
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00512-13
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