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Controlled insertional mutagenesis using a LINE-1 (ORFeus) gene-trap mouse model
A codon-optimized mouse LINE-1 element, ORFeus, exhibits dramatically higher retrotransposition frequencies compared with its native long interspersed element 1 counterpart. To establish a retrotransposon-mediated mouse model with regulatable and potent mutagenic capabilities, we generated a tetracy...
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| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3718180/ https://ncbi.nlm.nih.gov/pubmed/23818630 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1302504110 |
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