A Sleeping Beauty mutagenesis screen reveals a tumor suppressor role for Ncoa2/Src-2 in liver cancer

The Sleeping Beauty (SB) transposon mutagenesis system is a powerful tool that facilitates the discovery of mutations that accelerate tumorigenesis. In this study, we sought to identify mutations that cooperate with MYC, one of the most commonly dysregulated genes in human malignancy. We performed a...

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Detalhes bibliográficos
Main Authors: O’Donnell, Kathryn A., Keng, Vincent W., York, Brian, Reineke, Erin L., Seo, Daekwan, Fan, Danhua, Silverstein, Kevin A. T., Schrum, Christina T., Xie, Wei Rose, Mularoni, Loris, Wheelan, Sarah J., Torbenson, Michael S., O’Malley, Bert W., Largaespada, David A., Boeke, Jef D.
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2012
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3361419/
https://ncbi.nlm.nih.gov/pubmed/22556267
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115433109
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