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Retrotransposon Ty1 integration targets specifically positioned asymmetric nucleosomal DNA segments in tRNA hotspots

The Saccharomyces cerevisiae genome contains about 35 copies of dispersed retrotransposons called Ty1 elements. Ty1 elements target regions upstream of tRNA genes and other Pol III-transcribed genes when retrotransposing to new sites. We used deep sequencing of Ty1-flanking sequence amplicons to cha...

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Detalhes bibliográficos
Main Authors: Mularoni, Loris, Zhou, Yulian, Bowen, Tyson, Gangadharan, Sunil, Wheelan, Sarah J., Boeke, Jef D.
Formato: Artigo
Idioma:Inglês
Publicado em: Cold Spring Harbor Laboratory Press 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3317151/
https://ncbi.nlm.nih.gov/pubmed/22219510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gr.129460.111
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