Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Voltage-gated sodium (Na(v)) channels play a fundamental role in the generation and propagation of electrical impulses in excitable cells. Here we describe two unique structurally related nanomolar potent small molecule Na(v) channel inhibitors that exhibit up to 1,000-fold selectivity for human Na(...

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Bibliografiske detaljer
Main Authors: McCormack, Ken, Santos, Sonia, Chapman, Mark L., Krafte, Douglas S., Marron, Brian E., West, Christopher W., Krambis, Michael J., Antonio, Brett M., Zellmer, Shannon G., Printzenhoff, David, Padilla, Karen M., Lin, Zhixin, Wagoner, P. Kay, Swain, Nigel A., Stupple, Paul A., de Groot, Marcel, Butt, Richard P., Castle, Neil A.
Format: Artigo
Sprog:Inglês
Udgivet: National Academy of Sciences 2013
Fag:
PNAS Plus
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718154/
https://ncbi.nlm.nih.gov/pubmed/23818614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220844110
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