Voltage sensor interaction site for selective small molecule inhibitors of voltage-gated sodium channels

Voltage-gated sodium (Na(v)) channels play a fundamental role in the generation and propagation of electrical impulses in excitable cells. Here we describe two unique structurally related nanomolar potent small molecule Na(v) channel inhibitors that exhibit up to 1,000-fold selectivity for human Na(...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: McCormack, Ken, Santos, Sonia, Chapman, Mark L., Krafte, Douglas S., Marron, Brian E., West, Christopher W., Krambis, Michael J., Antonio, Brett M., Zellmer, Shannon G., Printzenhoff, David, Padilla, Karen M., Lin, Zhixin, Wagoner, P. Kay, Swain, Nigel A., Stupple, Paul A., de Groot, Marcel, Butt, Richard P., Castle, Neil A.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: National Academy of Sciences 2013
Pynciau:
PNAS Plus
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3718154/
https://ncbi.nlm.nih.gov/pubmed/23818614
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1220844110
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