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pH Modulates the Binding of EGR1 Transcription Factor to DNA

EGR1 transcription factor orchestrates a plethora of signaling cascades involved in cellular homeostasis and its down-regulation has been implicated in the development of prostate cancer. Herein, using a battery of biophysical tools, we show that the binding of EGR1 to DNA is tightly regulated by so...

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Autors principals: Mikles, David C., Bhat, Vikas, Schuchardt, Brett J., Deegan, Brian J., Seldeen, Kenneth L., McDonald, Caleb B., Farooq, Amjad
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716853/
https://ncbi.nlm.nih.gov/pubmed/23718776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/febs.12360
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