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An Unusual Pattern of Ligand-Receptor Interactions for the α7 Nicotinic Acetylcholine Receptor, with Implications for the Binding of Varenicline

The α7 nicotinic acetylcholine receptor shows broad pharmacology, complicating the development of subtype-specific nicotinic receptor agonists. Here we use unnatural amino acid mutagenesis to characterize binding to α7 by the smoking cessation drug varenicline (Chantix; Pfizer, Groton, CT), an α4β2-...

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Detaylı Bibliyografya
Asıl Yazarlar: Van Arnam, Ethan B., Blythe, Emily E., Lester, Henry A., Dougherty, Dennis A.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: The American Society for Pharmacology and Experimental Therapeutics 2013
Konular:
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716316/
https://ncbi.nlm.nih.gov/pubmed/23680636
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.113.085795
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