Effect of CYP3A5 Expression on the Inhibition of CYP3A-Catalyzed Drug Metabolism: Impact on Modeling CYP3A-Mediated Drug-Drug Interactions

The purpose of this study was to determine the impact of CYP3A5 expression on inhibitory potency (K(i) or IC(50) values) of CYP3A inhibitors, using recombinant CYP3A4 and CYP3A5 (rCYP3A4 and rCYP3A5) and CYP3A5 genotyped human liver microsomes (HLMs). IC(50) ratios between rCYP3A4 and rCYP3A5 (rCYP3...

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Bibliographische Detailangaben
Hauptverfasser: Shirasaka, Yoshiyuki, Chang, Shu-Ying, Grubb, Mary F., Peng, Chi-Chi, Thummel, Kenneth E., Isoherranen, Nina, Rodrigues, A. David
Format: Artigo
Sprache:Inglês
Veröffentlicht: The American Society for Pharmacology and Experimental Therapeutics 2013
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716306/
https://ncbi.nlm.nih.gov/pubmed/23723360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.112.049940
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