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Pharmacokinetics and Pharmacodynamics of Fluconazole for Cryptococcal Meningoencephalitis: Implications for Antifungal Therapy and In Vitro Susceptibility Breakpoints

Fluconazole is frequently the only antifungal agent that is available for induction therapy for cryptococcal meningitis. There is relatively little understanding of the pharmacokinetics and pharmacodynamics (PK-PD) of fluconazole in this setting. PK-PD relationships were estimated with 4 clinical is...

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Detalhes bibliográficos
Main Authors: Sudan, Ajay, Livermore, Joanne, Howard, Susan J., Al-Nakeeb, Zaid, Sharp, Andrew, Goodwin, Joanne, Gregson, Lea, Warn, Peter A., Felton, Tim W., Perfect, John R., Harrison, Thomas S., Hope, William W.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716186/
https://ncbi.nlm.nih.gov/pubmed/23571544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00216-13
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