Pharmacokinetics and Pharmacodynamics of Fluconazole for Cryptococcal Meningoencephalitis: Implications for Antifungal Therapy and In Vitro Susceptibility Breakpoints

Fluconazole is frequently the only antifungal agent that is available for induction therapy for cryptococcal meningitis. There is relatively little understanding of the pharmacokinetics and pharmacodynamics (PK-PD) of fluconazole in this setting. PK-PD relationships were estimated with 4 clinical is...

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Autors principals: Sudan, Ajay, Livermore, Joanne, Howard, Susan J., Al-Nakeeb, Zaid, Sharp, Andrew, Goodwin, Joanne, Gregson, Lea, Warn, Peter A., Felton, Tim W., Perfect, John R., Harrison, Thomas S., Hope, William W.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2013
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3716186/
https://ncbi.nlm.nih.gov/pubmed/23571544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00216-13
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