Dendritic Cell Expression of the Signaling Molecule TRAF6 is Critical for Gut Microbiota-Dependent Immune Tolerance

The intracellular signaling molecule TRAF6 is critical for Toll-like receptor (TLR)-mediated activation of dendritic cells (DCs). We now report that DC-specific deletion of TRAF6 (TRAF6ΔDC) resulted, unexpectedly, in loss of mucosal tolerance, characterized by spontaneous development of T helper 2 (...

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Bibliografische gegevens
Hoofdauteurs: Han, Daehee, Walsh, Matthew C., Cejas, Pedro J., Dang, Nicholas N., Kim, Youngmi F., Kim, Jihyun, Charrier-Hisamuddin, Laetitia, Chau, Lillian, Zhang, Qin, Bittinger, Kyle, Bushman, Frederic D., Turka, Laurence A., Shen, Hao, Reizis, Boris, DeFranco, Anthony L., Wu, Gary D., Choi, Yongwon
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: 2013
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Article
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3715143/
https://ncbi.nlm.nih.gov/pubmed/23791643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.immuni.2013.05.012
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