Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity

Nephrotoxicity severely limits the use of the anticancer drug cisplatin. Oxidative stress, inflammation, and endoplasmic reticulum (ER) stress contribute to cisplatin-induced nephrotoxicity. We developed novel orally active epoxyeicosatrienoic acid (EET) analogs and investigated their prophylactic e...

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Main Authors: Khan, Md. Abdul Hye, Liu, Jing, Kumar, Ganesh, Skapek, Stephen X., Falck, John R., Imig, John D.
Formato: Artigo
Idioma:Inglês
Publicado: Federation of American Societies for Experimental Biology 2013
Assuntos:
Research Communications
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714587/
https://ncbi.nlm.nih.gov/pubmed/23603837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-218040
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