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Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity

Nephrotoxicity severely limits the use of the anticancer drug cisplatin. Oxidative stress, inflammation, and endoplasmic reticulum (ER) stress contribute to cisplatin-induced nephrotoxicity. We developed novel orally active epoxyeicosatrienoic acid (EET) analogs and investigated their prophylactic e...

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Bibliographische Detailangaben
Hauptverfasser: Khan, Md. Abdul Hye, Liu, Jing, Kumar, Ganesh, Skapek, Stephen X., Falck, John R., Imig, John D.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Federation of American Societies for Experimental Biology 2013
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714587/
https://ncbi.nlm.nih.gov/pubmed/23603837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-218040
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