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Novel orally active epoxyeicosatrienoic acid (EET) analogs attenuate cisplatin nephrotoxicity

Nephrotoxicity severely limits the use of the anticancer drug cisplatin. Oxidative stress, inflammation, and endoplasmic reticulum (ER) stress contribute to cisplatin-induced nephrotoxicity. We developed novel orally active epoxyeicosatrienoic acid (EET) analogs and investigated their prophylactic e...

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Detalhes bibliográficos
Main Authors: Khan, Md. Abdul Hye, Liu, Jing, Kumar, Ganesh, Skapek, Stephen X., Falck, John R., Imig, John D.
Formato: Artigo
Idioma:Inglês
Publicado em: Federation of American Societies for Experimental Biology 2013
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714587/
https://ncbi.nlm.nih.gov/pubmed/23603837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-218040
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