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Sequence and structure-specific elements of HERG mRNA determine channel synthesis and trafficking efficiency
Human ether-á-gogo-related gene (HERG) encodes a potassium channel that is highly susceptible to deleterious mutations resulting in susceptibility to fatal cardiac arrhythmias. Most mutations adversely affect HERG channel assembly and trafficking. Why the channel is so vulnerable to missense mutatio...
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| Main Authors: | , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Federation of American Societies for Experimental Biology
2013
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3714577/ https://ncbi.nlm.nih.gov/pubmed/23608144 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1096/fj.12-227009 |
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