Genetic variants in telomerase-related genes are associated with an older age at diagnosis in glioma patients: evidence for distinct pathways of gliomagenesis

BACKGROUND: Genome-wide association studies have implicated single nucleotide polymorphisms (SNPs) in 7 genes as glioma risk factors, including 2 (TERT, RTEL1) involved in telomerase structure/function. We examined associations of these 7 established glioma risk loci with age at diagnosis among pati...

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Autors principals: Walsh, Kyle M., Rice, Terri, Decker, Paul A., Kosel, Matthew L., Kollmeyer, Thomas, Hansen, Helen M., Zheng, Shichun, McCoy, Lucie S., Bracci, Paige M., Anderson, Erik, Hsuang, George, Wiemels, Joe L., Pico, Alexander R., Smirnov, Ivan, Molinaro, Annette M., Tihan, Tarik, Berger, Mitchell S., Chang, Susan M., Prados, Michael D., Lachance, Daniel H., Sicotte, Hugues, Eckel-Passow, Jeanette E., Wiencke, John K., Jenkins, Robert B., Wrensch, Margaret R.
Format: Artigo
Idioma:Inglês
Publicat: Oxford University Press 2013
Matèries:
Basic and Translational Investigations
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3714154/
https://ncbi.nlm.nih.gov/pubmed/23733245
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/not051
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