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Design and Estimation for Evaluating Principal Surrogate Markers in Vaccine Trials
In vaccine research, immune biomarkers that can reliably predict a vaccine’s effect on the clinical endpoint (i.e., surrogate markers) are important tools for guiding vaccine development. This paper addresses issues on optimizing two-phase sampling study design for evaluating surrogate markers in a...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2013
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3713795/ https://ncbi.nlm.nih.gov/pubmed/23409839 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/biom.12014 |
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