Cone Phosphodiesterase-6α′ Restores Rod Function and Confers Distinct Physiological Properties in the Rod Phosphodiesterase-6β-Deficient rd10 Mouse

Phosphodiesterase-6 (PDE6) is the key effector enzyme of the vertebrate phototransduction pathway in rods and cones. Rod PDE6 catalytic core is composed of two distinct subunits, PDE6α and PDE6β, whereas two identical PDE6α′ subunits form the cone PDE6 catalytic core. It is not known whether this di...

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Auteurs principaux: Deng, Wen-Tao, Sakurai, Keisuke, Kolandaivelu, Saravanan, Kolesnikov, Alexander V., Dinculescu, Astra, Li, Jie, Zhu, Ping, Liu, Xuan, Pang, Jijing, Chiodo, Vince A., Boye, Sanford L., Chang, Bo, Ramamurthy, Visvanathan, Kefalov, Vladimir J., Hauswirth, William W.
Format: Artigo
Langue:Inglês
Publié: Society for Neuroscience 2013
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Articles
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713718/
https://ncbi.nlm.nih.gov/pubmed/23864662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.1536-13.2013
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