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The E3 ubiquitin ligase adaptor Ndfip1 regulates T(H)17 differentiation by limiting the production of pro-inflammatory cytokines
Ndfip1 is an adaptor for the E3 ubiquitin ligase Itch. Both Ndfip1- and Itch-deficient T cells are biased towards T(H)2 cytokine production. Here we demonstrate that lungs from Ndfip1(−/−) mice showed increased numbers of neutrophils and T(H)17 cells. This was not because Ndfip1−/− T cells are biase...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3713491/ https://ncbi.nlm.nih.gov/pubmed/22403444 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1102779 |
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