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Metabolism of R- and S-Warfarin by CYP2C19 into Four Hydroxywarfarins

Coumadin (R/S-warfarin) is a highly efficacious and widely used anticoagulant; however, its highly variable metabolism remains an important contributor to uncertainties in therapeutic responses. Pharmacogenetic studies report conflicting findings on the clinical relevance of CYP2C19. A resolution to...

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Detalhes bibliográficos
Main Authors: Kim, So-Young, Kang, Ji-Yeon, Hartman, Jessica H., Park, Sun-Ha, Jones, Drew R., Yun, Chul-Ho, Boysen, Gunnar, Miller, Grover P.
Formato: Artigo
Idioma:Inglês
Publicado em: 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713490/
https://ncbi.nlm.nih.gov/pubmed/23331088
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