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Metabolic Activation of Polycyclic Aromatic Hydrocarbons and Aryl and Heterocyclic Amines by Human Cytochromes P450 2A13 and 2A6

Human cytochrome P450 (P450) 2A13 was found to interact with several polycyclic aromatic hydrocarbons (PAHs) to produce Type I binding spectra, including acenaphthene, acenaphthylene, benzo[c]phenanthrene, fluoranthene, fluoranthene-2,3-diol, and 1-nitropyrene. P450 2A6 also interacted with acenapht...

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Bibliografiske detaljer
Main Authors: Shimada, Tsutomu, Murayama, Norie, Yamazaki, Hiroshi, Tanaka, Katsuhiro, Takenaka, Shigeo, Komori, Masayuki, Kim, Donghak, Guengerich, F. Peter
Format: Artigo
Sprog:Inglês
Udgivet: 2013
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3713097/
https://ncbi.nlm.nih.gov/pubmed/23432465
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx3004906
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