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Enthalpic Barriers Dominate the Folding and Unfolding of the Human Cu,Zn Superoxide Dismutase Monomer
The rate-limiting step in the formation of the native dimeric state of human Cu, Zn superoxide dismutase (SOD1) is a very slow monomer folding reaction that governs the lifetime of its unfolded state. Mutations at dozens of sites in SOD1 are known to cause a fatal motor neuron disease, amyotrophic l...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2012
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712906/ https://ncbi.nlm.nih.gov/pubmed/22999954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2012.09.009 |
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