Metal-Free ALS Variants of Dimeric Human Cu,Zn-Superoxide Dismutase Have Enhanced Populations of Monomeric Species

Amino acid replacements at dozens of positions in the dimeric protein human, Cu,Zn superoxide dismutase (SOD1) can cause amyotrophic lateral sclerosis (ALS). Although it has long been hypothesized that these mutations might enhance the populations of marginally-stable aggregation-prone species respo...

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書誌詳細
主要な著者: Svensson, Anna-Karin E., Bilsel, Osman, Kayatekin, Can, Adefusika, Jessica A., Zitzewitz, Jill A., Matthews, C. Robert
フォーマット: Artigo
言語:Inglês
出版事項: Public Library of Science 2010
主題:
Research Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2852398/
https://ncbi.nlm.nih.gov/pubmed/20404910
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010064
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