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Trim5 TAKes on Pattern Recognition
Retroviral capsids can be recognized and degraded by a host protein, Trim5α. A recent study in Nature shows that, upon sensing of the retrovirus capsid lattice, Trim5α generates free ubiquitin chains that activate the TAK1 kinase and downstream innate immune response genes.
Gorde:
| Egile Nagusiak: | , |
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| Formatua: | Artigo |
| Hizkuntza: | Inglês |
| Argitaratua: |
2011
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| Gaiak: | |
| Sarrera elektronikoa: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3712836/ https://ncbi.nlm.nih.gov/pubmed/21575904 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chom.2011.05.003 |
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