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Discordant Evolution of the Adjacent Antiretroviral Genes TRIM22 and TRIM5 in Mammals
TRIM5α provides a cytoplasmic block to retroviral infection, and orthologs encoded by some primates are active against HIV. Here, we present an evolutionary comparison of the TRIM5 gene to its closest human paralogs: TRIM22, TRIM34, and TRIM6. We show that TRIM5 and TRIM22 have a dynamic history of...
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| Hauptverfasser: | , , |
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| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2007
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2151084/ https://ncbi.nlm.nih.gov/pubmed/18159944 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.0030197 |
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