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Membrane Environment Imposes Unique Selection Pressures on Transmembrane Domains of G-protein Coupled Receptors

We have investigated the influence of the plasma membrane environment on the molecular evolution of G protein-coupled receptors (GPCRs), the largest receptor family in Metazoa. In particular, we have analyzed the site-specific rate variation across the two primary structural partitions, transmembran...

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Hlavní autoři: Spielman, Stephanie J., Wilke, Claus O.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712645/
https://ncbi.nlm.nih.gov/pubmed/23355009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00239-012-9538-8
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