Luteolin is a novel p90 ribosomal S6 kinase (RSK) inhibitor that suppresses Notch4 signaling by blocking the activation of Y-box binding protein-1 (YB-1)

Triple-negative breast cancers (TNBC) are notoriously difficult to treat because they lack hormone receptors and have limited targeted therapies. Recently, we demonstrated that p90 ribosomal S6 kinase (RSK) is essential for TNBC growth and survival indicating it as a target for therapeutic developme...

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Detalhes bibliográficos
Main Authors: Reipas, Kristen M., Law, Jennifer H., Couto, Nicole, Islam, Sumaiya, Li, Yvonne, Li, Huifang, Cherkasov, Artem, Jung, Karen, Cheema, Amarpal S., Jones, Steven J.M., Hassell, John A., Dunn, Sandra E.
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2013
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712578/
https://ncbi.nlm.nih.gov/pubmed/23593654
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