Extracellular Signal–Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle

Leptin is a key regulator of glucose metabolism in mammals, but the mechanisms of its action have remained elusive. We now show that signaling by extracellular signal–regulated kinase (ERK) and its upstream kinase MEK in the ventromedial hypothalamus (VMH) mediates the leptin-induced increase in glu...

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Detaylı Bibliyografya
Asıl Yazarlar: Toda, Chitoku, Shiuchi, Tetsuya, Kageyama, Haruaki, Okamoto, Shiki, Coutinho, Eulalia A., Sato, Tatsuya, Okamatsu-Ogura, Yuko, Yokota, Shigefumi, Takagi, Kazuyo, Tang, Lijun, Saito, Kumiko, Shioda, Seiji, Minokoshi, Yasuhiko
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: American Diabetes Association 2013
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712028/
https://ncbi.nlm.nih.gov/pubmed/23530005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1629
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