Extracellular Signal–Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle

Leptin is a key regulator of glucose metabolism in mammals, but the mechanisms of its action have remained elusive. We now show that signaling by extracellular signal–regulated kinase (ERK) and its upstream kinase MEK in the ventromedial hypothalamus (VMH) mediates the leptin-induced increase in glu...

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Bibliografski detalji
Glavni autori: Toda, Chitoku, Shiuchi, Tetsuya, Kageyama, Haruaki, Okamoto, Shiki, Coutinho, Eulalia A., Sato, Tatsuya, Okamatsu-Ogura, Yuko, Yokota, Shigefumi, Takagi, Kazuyo, Tang, Lijun, Saito, Kumiko, Shioda, Seiji, Minokoshi, Yasuhiko
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2013
Teme:
Original Research
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712028/
https://ncbi.nlm.nih.gov/pubmed/23530005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1629
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