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Induction of glucose uptake in skeletal muscle by central leptin is mediated by muscle β(2)-adrenergic receptor but not by AMPK

Leptin increases glucose uptake and fatty acid oxidation (FAO) in red-type skeletal muscle. However, the mechanism remains unknown. We have investigated the role of β(2)-adrenergic receptor (AR), the major β-AR isoform in skeletal muscle, and AMPK in leptin-induced muscle glucose uptake of mice. Lep...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Shiuchi, Tetsuya, Toda, Chitoku, Okamoto, Shiki, Coutinho, Eulalia A., Saito, Kumiko, Miura, Shinji, Ezaki, Osamu, Minokoshi, Yasuhiko
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5680211/
https://ncbi.nlm.nih.gov/pubmed/29123236
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-15548-6
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