Extracellular Signal–Regulated Kinase in the Ventromedial Hypothalamus Mediates Leptin-Induced Glucose Uptake in Red-Type Skeletal Muscle

Leptin is a key regulator of glucose metabolism in mammals, but the mechanisms of its action have remained elusive. We now show that signaling by extracellular signal–regulated kinase (ERK) and its upstream kinase MEK in the ventromedial hypothalamus (VMH) mediates the leptin-induced increase in glu...

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Bibliographische Detailangaben
Hauptverfasser: Toda, Chitoku, Shiuchi, Tetsuya, Kageyama, Haruaki, Okamoto, Shiki, Coutinho, Eulalia A., Sato, Tatsuya, Okamatsu-Ogura, Yuko, Yokota, Shigefumi, Takagi, Kazuyo, Tang, Lijun, Saito, Kumiko, Shioda, Seiji, Minokoshi, Yasuhiko
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2013
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3712028/
https://ncbi.nlm.nih.gov/pubmed/23530005
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db12-1629
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