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Boron-Based 4-Hydroxytamoxifen Bioisosteres for Treatment of de Novo Tamoxifen Resistant Breast Cancer
[Image: see text] Tamoxifen remains the first line therapy for estrogen receptor positive (ER+) breast cancer. However, polymorphisms of the gene encoding P450 2D6 could result in no protein expression or no CYP2D6 enzymatic activity and may significantly reduce the benefit of the hormone therapy. T...
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| Main Authors: | , , , , |
|---|---|
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
American
Chemical Society
2012
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| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3711775/ https://ncbi.nlm.nih.gov/pubmed/23864928 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml3000287 |
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