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Boronic Prodrug of Endoxifen as an Effective Hormone Therapy for Breast Cancer
As a prodrug, tamoxifen is activated by the P450 enzyme CYP2D6 that is responsible for converting it to the active metabolites, 4-hydroxytamoxifen and endoxifen. Patients with genetic polymorphisms of CYP2D6 may not receive the full benefit of tamoxifen therapy. There is increasing evidence that poo...
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| Udgivet i: | Breast Cancer Res Treat |
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| Main Authors: | , , , , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2015
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4524496/ https://ncbi.nlm.nih.gov/pubmed/26071758 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3461-9 |
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