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Boronic Prodrug of Endoxifen as an Effective Hormone Therapy for Breast Cancer

As a prodrug, tamoxifen is activated by the P450 enzyme CYP2D6 that is responsible for converting it to the active metabolites, 4-hydroxytamoxifen and endoxifen. Patients with genetic polymorphisms of CYP2D6 may not receive the full benefit of tamoxifen therapy. There is increasing evidence that poo...

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Detalhes bibliográficos
Publicado no:Breast Cancer Res Treat
Main Authors: Zhang, Changde, Zhong, Qiu, Zhang, Qiang, Zheng, Shilong, Miele, Lucio, Wang, Guangdi
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4524496/
https://ncbi.nlm.nih.gov/pubmed/26071758
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10549-015-3461-9
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