Sequencing of Fifty Human Exomes Reveals Adaptation to High Altitude

Residents of the Tibetan Plateau show heritable adaptations to extreme altitude. We sequenced 50 exomes of ethnic Tibetans, encompassing coding sequences of 92% of human genes, with an average coverage of 18X per individual. Genes showing population-specific allele frequency changes, which represent...

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Hlavní autoři: Yi, Xin, Liang, Yu, Huerta-Sanchez, Emilia, Jin, Xin, Cuo, Zha Xi Ping, Pool, John E., Xu, Xun, Jiang, Hui, Vinckenbosch, Nicolas, Korneliussen, Thorfinn Sand, Zheng, Hancheng, Liu, Tao, He, Weiming, Li, Kui, Luo, Ruibang, Nie, Xifang, Wu, Honglong, Zhao, Meiru, Cao, Hongzhi, Zou, Jing, Shan, Ying, Li, Shuzheng, Yang, Qi, Asan, Ni, Peixiang, Tian, Geng, Xu, Junming, Liu, Xiao, Jiang, Tao, Wu, Renhua, Zhou, Guangyu, Tang, Meifang, Qin, Junjie, Wang, Tong, Feng, Shuijian, Li, Guohong, Huasang, Luosang, Jiangbai, Wang, Wei, Chen, Fang, Wang, Yading, Zheng, Xiaoguang, Li, Zhuo, Bianba, Zhuoma, Yang, Ge, Wang, Xiznping, Tang, Shuhui, Gao, Guoyi, Chen, Yong, Luo, Zhen, Gusang, Lamu, Cao, Zheng, Zhang, Qinghui, Ouyang, Weihan, Ren, Xiaoli, Liang, Huiqing, Zheng, Huisong, Huang, Yebo, Li, Jingxiang, Bolund, Lars, Kristiansen, Karsten, Li, Yingrui, Zhang, Yong, Zhang, Xiuqing, Li, Ruiqiang, Li, Songgang, Yang, Huanming, Nielsen, Rasmus, Wang, Jun, Wang, Jian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3711608/
https://ncbi.nlm.nih.gov/pubmed/20595611
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.1190371
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